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Umeå universitet
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Personalbild Andrei Chabes

Andrei Chabes

Professor i medicinsk kemi

dNTP: genomets byggstenar

Kontakt

E-post
andrei.chabes@umu.se
Telefon
073-620 54 46

Verksam som

Anknytning
Professor vid Institutionen för medicinsk kemi och biofysik Roll: Katalogansvarig
Plats
KBC building, H6, Campus, dg club, A6-28-13 dg club, 901 87 dg club
Anknytning
Anknuten som övrig/annan befattning till Wallenberg centrum för molekylär medicin vid dg club (WCMM) Roll: Föreståndare
Plats
dg club, 901 87 dg club

DNA byggs upp av fyra olika byggstenar – dATP, dTTP, dGTP och dCTP – som tillsammans kallas dNTP.
Målet med mitt projekt är att förstå hur förändringar i mängden av dessa byggstenar påverkar genomets stabilitet, cellens åldrande och uppkomsten av sjukdomar. Vi strävar också efter att utveckla nya metoder för att motverka dessa sjukdomar genom att justera nivåerna av DNA-byggstenarna på ett riktat sätt.

Urval av senaste publikationer:

Awoyomi OF, Gorospe CM, Das B, Mishra P, Sharma S, Diachenko O, Nilsson AK, Tran P, Wanrooij PH and Chabes A (2025) RRM2B deficiency causes dATP and dGTP depletion through enhanced degradation and slower synthesis.

Tran P, Mishra P, Williams LG, Moskalenko R, Sharma S, Nilsson AK, Watt DL, Andersson P, Bergh A, Pursell ZF and Chabes A (2024) Altered dNTP pools accelerate tumor formation in mice.  

Das B, Mishra P, Pandey P, Sharma, S and Chabes, A (2022) dNTP concentrations do not increase in mammalian cells in response to DNA damage.  

Wanrooij PH, Tran P, Thompson LJ, Carvalho G, Sharma S, Kreisel K, Navarrete C, Feldberg AL, Watt DL, Nilsson AK, Engqvist MKM, Clausen AR and Chabes A (2020) Elimination of rNMPs from mitochondrial DNA has no effect on its stability.

Sushma S, Koolmeister C, Tran P, Nilsson AK, Larsson NG and Chabes A (2020) Proofreading deficiency in mitochondrial DNA polymerase does not affect total dNTP pools in mouse embryos.  

Alla publikationer i och i .

 

 

Proceedings of the National Academy of Sciences of the United States of America, Proceedings of the National Academy of Sciences (PNAS) 2025, Vol. 122, (16)
Awoyomi, Ololade Folajimi; Gorospe, Choco Michael; Das, Biswajit; et al.
Nature Communications, Springer Nature 2025, Vol. 16, (1)
van der Horst, Sophie C.; Kollenstart, Leonie; Batté, Amandine; et al.
Nature Communications, Springer Nature 2024, Vol. 15, (1)
de Jaime-Soguero, Anchel; Hattemer, Janina; Bufe, Anja; et al.
Nucleic Acids Research, Oxford University Press 2024, Vol. 52, (20) : 12475-12486
Tran, Phong; Mishra, Pradeep; Williams, Leonard G.; et al.
DNA Repair, Elsevier 2023, Vol. 129
Dmowski, Michal; Makiela-Dzbenska, Karolina; Sharma, Sushma; et al.
Mitochondrial DNA: methods and protocols, New York: Humana Press 2023 : 267-280
Sharma, Sushma; Kong, Ziqing; Jia, Shaodong; et al.
EMBO Journal, John Wiley & Sons 2023, Vol. 42, (18)
Wanrooij, Paulina H.; Chabes, Andrei
Life Science Alliance, Vol. 5, (4)
Batté, Amandine; van der Horst, Sophie C.; Tittel-Elmer, Mireille; et al.
Cell Metabolism, Elsevier 2022, Vol. 34, (12) : 1895-1896
Das, Biswajit; Mishra, Pradeep; Pandey, Praveen; et al.
DNA Repair, Elsevier 2022, Vol. 110
Dmowski, Michal; Jedrychowska, Malgorzata; Makiela-Dzbenska, Karolina; et al.
Nucleic Acids Research, Oxford University Press 2022, Vol. 50, (3)
Ranjbarian, Farahnaz; Sharma, Sushma; Falappa, Giulia; et al.
Nucleic Acids Research, Oxford Academic 2020, Vol. 48, (8) : 4274-4297
Cerritelli, Susana M; Iranzo, Jaime; Sharma, Sushma; et al.
Comptes rendus. Biologies, Académie des Sciences 2020, Vol. 343, (1) : 9-21
Coquel, F.; Silva, M. J.; Techer, H.; et al.
Cell Reports, Elsevier 2020, Vol. 31, (6)
Davenne, Tamara; Klintman, Jenny; Sharma, Sushma; et al.
Molecular Cell, Elsevier 2020, Vol. 78, (3) : 496-410.e4
Forey, Romain; Poveda, Ana; Sharma, Sushma; et al.
Nucleic Acids Research, Oxford University Press 2020, Vol. 48, (1) : 264-277
Schmidt, Tobias T; Sharma, Sushma; Reyes, Gloria X; et al.
Nature Metabolism, Nature Publishing Group 2020, Vol. 2, (8) : 673-675
Sharma, Sushma; Koolmeister, Camilla; Tran, Phong; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2020, Vol. 117, (25) : 14306-14313
Wanrooij, Paulina H.; Tran, Phong; Thompson, Liam J.; et al.
FEBS Open Bio, WILEY 2019, Vol. 9 : 21-21
Chabes, Andrei
The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (8) : 3986-3995
Garbacz, Marta A.; Cox, Phillip B.; Sharma, Sushma; et al.
Molecular Cell, Elsevier 2019, Vol. 76, (5) : 784-+
Nicholls, Thomas J.; Spåhr, Henrik; Jiang, Shan; et al.
PLOS ONE, Public Library of Science 2019, Vol. 14, (3)
Rentoft, Matilda; Svensson, Daniel; Sjödin, Andreas; et al.
Nucleic Acids Research, Oxford University Press 2019, Vol. 47, (1) : 237-252
Schmidt, Tobias T.; Sharma, Sushma; Reyes, Gloria X.; et al.
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology 2019, Vol. 394, (44) : 15889-15897
Tran, Phong; Wanrooij, Paulina H.; Lorenzon, Paolo; et al.
FEBS Letters, John Wiley & Sons 2019, Vol. 593, (13) : 1554-1565
Wanrooij, Paulina H.; Chabes, Andrei
Nature Communications, Nature Publishing Group 2019, Vol. 10
Xing, Xuanxuan; Kane, Daniel P.; Bulock, Chelsea R.; et al.
EMBO Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (21)
Bacal, Julien; Moriel-Carretero, María; Pardo, Benjamin; et al.
Nature, Vol. 557, (7703) : 57-61
Coquel, Flavie; Silva, Maria-Joao; Técher, Hervé; et al.
Nucleic Acids Research, Oxford University Press 2018, Vol. 46, (11)
Kong, Ziqing; Jia, Shaodong; Chabes, Anna Lena; et al.
Genes & Development, Vol. 32, (11-12) : 822-835
Lanz, Michael Charles; Oberly, Susannah; Sanford, Ethan James; et al.
EMBO Journal, Wiley-VCH Verlagsgesellschaft 2018, Vol. 37, (17)
Li, Shuqi; Xu, Zhiyun; Xu, Jiawei; et al.
PLOS Genetics, PUBLIC LIBRARY SCIENCE 2018, Vol. 14, (1)
Peng, Xiao P.; Lim, Shelly; Li, Shibai; et al.
Upregulation of dNTP Levels After Telomerase Inactivation Influences Telomerase-Independent Telomere Maintenance Pathway Choice in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, Vol. 8, (8) : 2551-2558
van Mourik, Paula M; de Jong, Jannie; Sharma, Sushma; et al.
Science, American Association for the Advancement of Science 2018, Vol. 361, (6409) : 1386-+-
Yu, Chuanhe; Gan, Haiyun; Serra-Cardona, Albert; et al.
Molecular Cell, Elsevier 2017, Vol. 68, (2) : 446-455
Gan, Haiyun; Yu, Chuanhe; Devbhandari, Sujan; et al.
Oncogene, Macmillan Publishers Ltd. 2017, Vol. 36, (42) : 5808-5818
Garzón, J.; Rodríguez, R.; Kong, Ziqing; et al.
Nucleic Acids Research, Vol. 45, (3) : 1200-1218
Kochenova, Olga V; Bezalel-Buch, Rachel; Tran, Phong; et al.
PLOS Genetics, Vol. 13, (10)
Maicher, André; Gazy, Inbal; Sharma, Sushma; et al.
Journal of Hepatology, ELSEVIER SCIENCE BV 2017, Vol. 66, (1) : S321-S321
Nystrom, K.; Pettersson, G.; Wanrooij, Paulina; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 114, (22) : E4442-E4451
Schmidt, Tobias T; Reyes, Gloria; Gries, Kerstin; et al.
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences 2017, Vol. 114, (47) : 12466-12471
Wanrooij, Paulina H.; Engqvist, Martin K. M.; Forslund, Josefin M. E.; et al.
Nucleic Acids Research, Vol. 44, (9) : 4222-4232
Kenigsberg, Ephraim; Yehuda, Yishai; Marjavaara, Lisette; et al.
Cell Reports, Vol. 17, (6) : 1657-1670
Liew, Li Phing; Lim, Zun Yi; Cohen, Matan; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, (17) : 4723-4728
Rentoft, Matilda; Lindell, Kristoffer; Tran, Phong; et al.
Nucleic Acids Research, Vol. 44, (4) : 1669-1680
Watt, Danielle L.; Buckland, Robert J.; Lujan, Scott A.; et al.
Oncotarget, Vol. 6, (14) : 12587-12602
Barfeld, Stefan J; Fazli, Ladan; Persson, Margareta; et al.
Yeast, Wiley-Blackwell 2015, Vol. 32, (Suppl. 1) : S56-S56
Earp, Caroline; Rowbotham, Samuel; Marjavaara, Lisette; et al.
Biology open, Vol. 4, (12) : 1739-1743
Earp, Caroline; Rowbotham, Samuel; Merényi, Gábor; et al.
DNA Replikation: Methods and Protocols, New York: Springer-Verlag New York 2015 : 113-121
Jia, Shaodong; Marjavaara, Lisette; Buckland, Robert; et al.
Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, (19) : E2467-E2476
Mertz, Tony M; Sharma, Sushma; Chabes, Andrei; et al.

Forskargrupper

Forskningsledare
Andrei Chabes Lab
Andrei Chabes: Kan sjukdomar botas med hjälp av DNAs byggstenar?

Brist på DNAs byggstenar i vilande celler, leder till sjukdomar hos både barn och vuxna.